Products from LC Laboratories

LC Laboratories

LC Laboratories from Woburn, Massachusetts is manufacturing small-molecule reagents since 1980. Numerous reagent vendors sell LC Laboratories` top-quality products under their own labels. If you do signal transduction, oncology or other preclinical research, you have probably been relying on LC Labs products, directly or indirectly, from the time you started your research.

More information at: www.lclabs.com

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Cobimetinib, Free Base
Cobimetinib, Free Base

Item number: LC-C-1100_100mg

Soluble in DMSO. Cobimetinib demonstrated a sustained tumor pharmacodynamic response due to longer residence times in tumor tissue than in plasma in mice. Following single doses, cobimetinib inhibited pERK in tumors with IC50 values of 780 nM in WM-266-4 and 520 nM in A375 xenograft mice. Following multiple doses,...
Keywords: GDC0973, RG7420, XL518
Application: Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor
CAS 934660-93-2
MW: 531.31 D
From 76.00€ *
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Daunorubicin, Hydrochloride Salt
Daunorubicin, Hydrochloride Salt

Item number: LC-D-6660_100mg

Soluble in DMSO. Daunorubicin, also known as daunomycin, is an anthracycline antibiotic that is one of the major antitumor agents widely used in the treatment of acute myeloid leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, and Kaposi's sarcoma. Daunomycin and Actinomycin reduced mitotic activity...
Keywords: Cerubidine, Daunoblastin, NDC 0082-4155, Ondena, RP 13057, Rubidomycin
Application: Antineoplastic, Topoisomerase II inhibitor
CAS 23541-50-6
MW: 563.98 D
From 72.00€ *
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GW7647, Free Acid
GW7647, Free Acid

Item number: LC-G-1111_100mg

Soluble in DMSO. GW7647 is a peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist. A synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and GW7647 was demonstrated in a model of acute chemical-induced pain. Russo R., et al. 'Synergistic...
Application: Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist
CAS 265129-71-3
MW: 502.75 D
From 68.00€ *
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GW590735, Free Acid
GW590735, Free Acid

Item number: LC-G-7322_100mg

Soluble in DMSO. GW590735 is a potent and selective PPARalpha agonist. It stimulated PPARalpha with an EC50 of 4 nM and had at least 500-fold selectivity on PPARalpha versus PPARdelta and PPARgamma. It raised circulating levels of high-density lipoprotein cholesterol. Sierra M.L., et al. 'Substituted...
Application: Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist
CAS 622402-22-6
MW: 478.48 D
From 90.00€ *
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Imatinib, Free Base
Imatinib, Free Base

Item number: LC-I-5577_10g

Solubility: Soluble in DMSO at 25 mg/mL with slight warming, soluble in ethanol at 5 mg/mL with slight warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 5-20 µM, buffers, serum, or other additives may increase or decrease. This is the free base form of imatinib, please...
Keywords: CGP-57148B, STI-571
Application: Antineoplastic, Tyrosine kinase inhibitor
CAS 152459-95-5
MW: 493.6 D
From 82.00€ *
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Lenvatinib, Free Base
Lenvatinib, Free Base

Item number: LC-L-5400_100mg

Soluble in DMSO. Lenvatinib, also known as E7080, is an active inhibitor of multiple receptor tyrosine kinases, with IC50 values of 22 nM (VEGFR1), 4 nM (VEGFR2), 5.2 nM (VEGFR3), 46 nM (FGFR1), 51 nM (PDGFRa), 39 nM (PDGFRb), and 100 nM (KIT). It inhibited SCF- and VEGF-induced angiogenesis of human umbilical vein...
Keywords: E7080, ER20349200
Application: Antineoplastic, Receptor tyrosine kinase inhibitor
CAS 417716-92-8
MW: 426.85 D
From 72.00€ *
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Niraparib, Free Base
Niraparib, Free Base

Item number: LC-N-5665_100mg

Soluble in DMSO. Niraparib, also known as MK-4827, is a poly(ADP-ribose)polymerase (PARP) inhibitor. Niraparib displayed excellent PARP 1 and 2 inhibition with IC50 values of 3.8 and 2.1 nM, respectively, and in a whole cell assay, it inhibited PARP activity with an IC50 of 4 nM, and inhibited proliferation of...
Keywords: MK-4827
Application: Antineoplastic, PARP inhibitor
CAS 1038915-60-4
MW: 320.39 D
From 75.00€ *
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Niraparib, p-Toluenesulfonate Salt
Niraparib, p-Toluenesulfonate Salt

Item number: LC-N-5688_100mg

Soluble in DMSO. Niraparib enhanced radiation-induced cytotoxicity in neuroblastoma cells. In vivo treatment with niraparib and radiation prolonged survival of mice in a murine xenograft model of metastatic neuroblastoma when compared to single modalities. Mueller S., et al. 'Poly (ADP-Ribose) polymerase inhibitor...
Keywords: MK-4827
Application: Antineoplastic, PARP inhibitor
CAS 1038915-73-9
MW: 492.59 D
From 75.00€ *
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Nilotinib, Hydrochloride Salt, Monohydrate
Nilotinib, Hydrochloride Salt, Monohydrate

Item number: LC-N-8266_10g

Soluble in DMSO. Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL...
Keywords: AMN-107
Application: Antineoplastic, Tyrosine kinase inhibitor
CAS 923288-90-8
MW: 584 D
From 80.00€ *
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Pemafibrate, Free Acid
Pemafibrate, Free Acid

Item number: LC-P-5115_100mg

Soluble in DMSO.
Keywords: K-877, R-K-13675
Application: Antihyperlipidemic, Triglyceride synthesis inhibitor, PPAR alpha agonist
CAS 848259-27-8
MW: 490.55 D
From 76.00€ *
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PLX4720, Free Base
PLX4720, Free Base

Item number: LC-P-8900_100mg

Soluble in DMSO. PLX4720 is a kinase inhibitor with marked selectivity against B-Raf(V600E), with an IC50 of 13 nM. PLX4720 induced cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells in melanoma models. In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor growth...
Keywords: Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
Application: B-Raf(V600E) inhibitor
CAS 918505-84-7
MW: 413.83 D
From 77.00€ *
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SB431542, Free Base
SB431542, Free Base

Item number: LC-S-7800_100mg

Soluble in DMSO. SB-431542 selectively inhibited Smad3 phosphorylation, with an IC50 of 94 nM. It also blocked TGF-beta1-induced nuclear Smad3 localization. Laping N.J., et al. 'Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor...
Keywords: SB 431542, 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate,...
Application: Smad3 phosphorylation inhibitor, TGFBR1/ALK4/ALK7 kinase inhibitor
CAS 301836-41-9
MW: 384.39 D
From 82.00€ *
Review
2 from 15 pages