Products from LC Laboratories
LC Laboratories from Woburn, Massachusetts is manufacturing small-molecule reagents since 1980. Numerous reagent vendors sell LC Laboratories' top-quality products under their own labels. If you do signal transduction, oncology or other pre-clinical research, you have probably been relying on LC Labs products, directly or indirectly, from the time you started your research.
More information at: www.lclabs.com
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Niraparib, Free Base
Item number: LC-N-5665_100mg
Soluble in DMSO. Niraparib, also known as MK-4827, is a poly(ADP-ribose)polymerase (PARP) inhibitor. Niraparib displayed excellent PARP 1 and 2 inhibition with IC50 values of 3.8 and 2.1 nM, respectively, and in a whole cell assay, it inhibited PARP activity with an IC50 of 4 nM, and inhibited proliferation of...
| Keywords: | MK-4827 |
| Application: | Antineoplastic, PARP inhibitor |
| CAS | 1038915-60-4 |
| MW: | 320.39 D |
From 86.00€
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Niraparib, p-Toluenesulfonate Salt
Item number: LC-N-5688_100mg
Soluble in DMSO. Niraparib enhanced radiation-induced cytotoxicity in neuroblastoma cells. In vivo treatment with niraparib and radiation prolonged survival of mice in a murine xenograft model of metastatic neuroblastoma when compared to single modalities. Mueller S., et al. 'Poly (ADP-Ribose) polymerase inhibitor...
| Keywords: | MK-4827 |
| Application: | Antineoplastic, PARP inhibitor |
| CAS | 1038915-73-9 |
| MW: | 492.59 D |
From 86.00€
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PLX4720, Free Base
Item number: LC-P-8900_100mg
Soluble in DMSO. PLX4720 is a kinase inhibitor with marked selectivity against B-Raf(V600E), with an IC50 of 13 nM. PLX4720 induced cell cycle arrest and apoptosis exclusively in B-Raf(V600E)-positive cells in melanoma models. In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor growth...
| Keywords: | Raf Kinase Inhibitor V, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Application: | B-Raf(V600E) inhibitor |
| CAS | 918505-84-7 |
| MW: | 413.83 D |
From 88.00€
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FK-506 (Tacrolimus, Fujimycin, FK506, Prograf, CAS...
Item number: LC-F-4900_50mg
Soluble in DMSO at 100 mg/mL, soluble in ethanol at 100 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Keywords: | Tacrolimus,... |
| Application: | Immunosuppressant |
| CAS | 104987-11-3 |
| MW: | 804,02 D |
From 109.00€
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Capecitabine (Capecitabin, Capecitibine, Capecytabine,...
Item number: LC-C-2799_10g
Soluble in DMSO at 100 mg/mL, soluble in ethanol at 12.5 mg/mL with slight warming, soluble in water at 2 mg/mL with slight warming, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Keywords: | Ro 09-1978, Xeloda(R), 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine |
| Application: | Prodrug for 5-fluorouracil |
| CAS | 154361-50-9 |
| MW: | 359,35 D |
From 91.00€
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Osimertinib, Free Base (AZD9291, Mereletinib, Tagrisso,...
Item number: LC-O-7200_500mg
Soluble in DMSO
| Keywords: | N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide |
| Application: | Mutant-selective EGFR inhibitor |
| CAS | 1421373-65-0 |
| MW: | 499,61 D |
From 87.00€
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Bosutinib Isomer 1, Free Base (CAS 1391063-17-4), >99%
Item number: LC-B-1722_25mg
Soluble in DMSO at 33 mg/mL, soluble in ethanol at 10 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-50 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| CAS | 1391063-17-4 |
| MW: | 530,45 D |
From 80.00€
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Saracatinib, Free Base (AZD-0530, CAS 379231-04-6), >99%
Item number: LC-S-8906_200mg
Soluble in DMSO at 200 mg/mL, soluble in ethanol at 200 mg/mL with warming, very poorly soluble in water, maximum solubility in plain water is estimated to be about 20-100 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Keywords: | AZD 0530,... |
| Application: | c-Src / Abl inhibitor |
| CAS | 379231-04-6 |
| MW: | 542,03 D |
From 367.00€
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