Products from Chimerigen Laboratories
Chimerigen develops and manufactures unique, immunoglobulin-based, chimeric fusion proteins and related research products using advanced cellular and molecular biological techniques. These reagents are used successfully in basic biomedical and applied research.
More information at: www.adipogen.com/chimerigen
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Tim-4 (human):Fc (human) (rec.)
Item number: CHI-HF-210T4-C100
The extracellular domain of human Tim-4 (aa 25-314) is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized from 0.2µm-filtered solution in PBS. The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant...
| Keywords: | TIM4, TIM-4, TIMD4, TIMD-4, T-cell membrane protein 4, T-cell immunoglobulin and mucin domain-containing protein 4 |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
523.00€
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TGFbeta1 (mutant) (human):Fc (human) (rec.)
Item number: CHI-HF-210TGFBM-C100
The extracellular domain of a mutant human TGFbeta1 is fused at the C-terminus to the Fc portion of human IgG4. Site-directed mutagenesis was used to change three cysteine codons into a serine codon that are located in the pro region of the TGF-beta precursor at amino acid positions 33, 223, and 225. Lyophilized...
| Keywords: | LAP, TGFB, TGFB1, TGF-beta-1, Latency-associated peptide, Transforming growth factor beta-1 |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
523.00€
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Thrombospondin-1 (human):Fc (human) (rec.)
Item number: CHI-HF-210TSP1-C050
Thrombospondin-1 (TSP1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. Within the thrombospondin family, TSP-2 is also homotrimeric, while TSP-3, -4, and -5/COMP are homopentameric. TSP-1 regulates a wide range of cellular functions including their interactions with...
| Keywords: | TSP1, TSP, THBS1, Thrombospondin-1 |
| Application: | Bioassays |
| Expressed in: | Human cells |
| Origin: | human |
369.00€
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CD252 [OX40L] (human):Fc (mouse) (rec.)
Item number: CHI-HF-211CD252-C100
OX40L [CD252, TNFSF4] is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic...
| Keywords: | CD252, Ox40l, OX40L, Tnfsf4, OX40 ligand, Tumor necrosis factor ligand superfamily member 4, TNFSF4 |
| Application: | Bioassays |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | ~55 kD |
429.00€
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Tim-3 (human):Fc (mouse) (rec.)
Item number: CHI-HF-211T3-C100
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific...
| Keywords: | TIM3, TIM-3, TIMD-3, HAVCR2, HAVcr-2, T-cell membrane protein 3, Hepatitis A virus cellular receptor 2, T-cell... |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
523.00€
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IL-7 (human):Fc (human) (rec.) (non-lytic)
Item number: CHI-HF-22007-C050
The extracellular domain of human IL-7 (aa 26-177) is fused to the N-terminus of the Fc portion of a mutant human IgG1. IL-7 protein function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation....
| Keywords: | IL7, IL-7, Interleukin-7 |
| Application: | Cell proliferation stimulator of mouse 2E8 cells |
| Expressed in: | Hamster cells |
| Origin: | human |
523.00€
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EPO (human):Fc (human) (rec.) (non-lytic)
Item number: CHI-HF-220EPO-C050
Protein function: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. [The Uniprot Consortium]
| Keywords: | EPO, Epoetin, Erythropoietin |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | human |
429.00€
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Fc (human) IgG1 Control (rec.) (non-lytic)
Item number: CHI-HF-220IG1-C100
This product should be used as the control protein for activity tests of fusion proteins including human target proteins and human IgG-Fc domains.
| Keywords: | IGHG1, Ig gamma-1 chain C region, |
| Application: | Bioassays |
| Expressed in: | Human cells |
| Origin: | human |
| MW: | ~26 kD |
391.00€
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CD137 (human) (rec.) (His)
Item number: CHI-HR-200CD137-C025
Human CD137 (aa 19-184) is fused at the C-terminus to a His-tag. Human CD137 (4-1BB) is a costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4+ and CD8+ T cells and binds to a high-affinity ligand (4-1BBL) expressed on several...
| Keywords: | CD137, CDw137, TNFRSF9, T-cell antigen ILA, 4-1BB ligand receptor, T-cell antigen 4-1BB homolog, Tumor necrosis factor... |
| Application: | Bioassays |
| Expressed in: | E.coli |
| Origin: | human |
352.00€
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HMGB1 (human) (rec.) (His)
Item number: CHI-HR-200HMGB1-C025
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac,...
| Keywords: | HMG1, HMG-1, HMGB1, High mobility group protein 1, High mobility group protein B1 |
| Application: | Bioassays |
| Expressed in: | E.coli |
| Origin: | human |
325.00€
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CD74 (mouse):Fc (mouse) (rec.)
Item number: CHI-MF-110CD74-C100
CD74 is a transmembrane protein which, on antigen presenting cells, is the invariant chain that chaperones MHC class II dimers from the endoplasmic reticulum to the cell surface. The cytoplasmic portion of CD74 can be released by intramembrane cleavage to activate NFkB. CD74 is upregulated in several cancers and is...
| Keywords: | Ii, CD74, Cd74, Ia antigen-associated invariant chain, MHC class II-associated invariant chain, H-2 class II... |
| Application: | Bioassays |
| Expressed in: | Human cells |
| Origin: | mouse |
| MW: | ~55 kD |
429.00€
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CD279 [PD-1] (mouse):Fc (mouse) (rec.)
Item number: CHI-MF-110PD1-C100
The extracellular domain of mouse CD279 [PD-1] (aa 26-169) is fused to the N-terminus of the Fc region of mouse IgG2a. CD279 (Programmed Cell Death Protein 1, PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members...
| Keywords: | Pd1, CD279, mPD-1, Pdcd1, Protein PD-1, Programmed cell death protein 1 |
| Application: | Bioassays |
| Expressed in: | Hamster cells |
| Origin: | mouse |
429.00€
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