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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay600007-384 | 384 wells | - |
6 - 10 business days* |
554.00€
|
|||
Cay600007-1920 | 1920 wells | - |
6 - 10 business days* |
2,069.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Prostaglandin D2 (PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells... more
Product information "Prostaglandin D Synthase (hematopoietic-type) FP-Based Inhibitor Screening Assay Kit - Green"
Prostaglandin D2 (PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. H-PGDS is therefore a key target for development of selective, potent inhibitors for therapeutic use against these diseases. Cayman's H-PGDS FP-Based Inhibitor Screening Assay Kit - Green provides a rapid, accurate assay for screening H-PGDS inhibitors. In this assay, a H-PGDS inhibitor-fluorescein conjugate serves as a specific fluorescent probe for the enzyme. Displacement of the probe by any unlabeled H-PGDS inhibitor leads to a decrease in the fluorescence polarization (FP) state of the probe, providing a direct signal for binding of the inhibitor to the active site of the enzyme. This assay is robust (Z' of 0.75) and eliminates the need for the traditional multistep assay that requires the use of highly unstable PGH2. The assay has been validated using several known inhibitors of H-PGDS with IC50 values ranging from nanomolar to millimolar concentrations.Synonyms: Prostaglandin D Synthase (hematopoietic-type) Fluorescence Polarization-Based Inhibitor Screening Assay Kit - Green, H-PGDS FP-Based Inhibitor Screening Assay Kit - Green.
Keywords: | H-PGDS FP-Based Inhibitor Screening Assay Kit - Green, Prostaglandin D Synthase (hematopoietic-type) Fluorescence Polarization-Based Inhibitor Screening Assay Kit - Green |
Supplier: | Cayman Chemical |
Supplier-Nr: | 600007 |
Properties
Application: | PGDS inhibitor screening |
Species reactivity: | human |
Format: | Homog. |
Database Information
KEGG ID : | K04097 | Matching products |
UniProt ID : | O60760 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H225, H227, H315, H316, H319 |
P Phrases: | P210, P233, P240, P241, P242, P243, P264, P280, P302+352, P303+361+353, P305+351+338, P321, P332+313, P337+313, P362+364, P370+378, P403, P403+235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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