Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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DEAE-dex-Cy5
Item number: TGM-T203109-10mg
Description: DEAE-dex-Cy5 is a fluorescent labeling reagent that combines the Cy5 fluorescent dye with Dextran (dex) and diethylaminoethyl (DEAE). Cy5, a cyanine dye, has a wavelength of approximately 662 nm and is used for molecular labeling and microscopic imaging. Dextran inhibits platelet aggregation and...
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GuaB-IN-1
Item number: TGM-T203122-10mg
Description: GuaB-IN-1 (Compound 15) is effective against M.tb with a MIC value of 0.25 µM. At a concentration of 10 µM, GuaB-IN-1 exhibits a 28% inhibition of hERG. This compound holds promise for tuberculosis research.
| MW: | 423.85 D |
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Adhibin
Item number: TGM-T203163-10mg
Description: Adhibin is an allosteric inhibitor of RhoGAP class IX myosin (RhoGAP class IXmyosin), effectively inhibiting Myo9 ATPase in both mammals and invertebrates with an IC50 of 2.5 µM and 2.6 µM, respectively. It binds to ATPase, disrupting myosin's motor functions, blocking RhoGTPase-related signaling...
| MW: | 355.02 D |
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PROTAC KSP-IN-1
Item number: TGM-T203186-10mg
Description: PROTACKSP-IN-1 (Compound 21) is a spindle protein (KSP) degrader as a PROTAC, effectively degrading KSP in HCT-116 cells with a DC50 value of 114.8 nM. It inhibits the proliferation of HCT-116 with an IC50 of 10 nM, causes G2/M phase cell cycle arrest, and induces apoptosis in HCT-116. Additionally,...
| MW: | 858.01 D |
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Alexa Fluor 430 NHS ester
Item number: TGM-T203214-10mg
Description: Alexa Fluor 430 NHS ester is a compound used to conjugate the green fluorescent dye Alexa Fluor 430 with proteins or antibodies. Alexa Fluor 430 provides stable signal generation in imaging and flow cytometry. The NHS ester is suitable for labeling proteins, amine-modified oligonucleotides, and other...
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CCR8 agonist 1
Item number: TGM-T203220-10mg
Description: CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases. Target: CCR
| MW: | 355.47 D |
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AChE/BChE-IN-25
Item number: TGM-T203222-10mg
Description: AChE/BChE-IN-25 (Compound 6e) is an orally active inhibitor of hAChE and eqBChE, with IC50 values of 7.9 nM and 0.79 nM, respectively. This compound exhibits antioxidant activity, effective in scavenging free radicals with an IC50 of 22.91 µM. AChE/BChE-IN-25 demonstrates neuroprotective effects by...
| MW: | 385.89 D |
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Nrf2 activator 18
Item number: TGM-T203243-10mg
Description: Nrf2 activator 18 (Compound 11a) is an orally active activator of the Keap1/Nrf2/HO-1 signaling pathway, promoting Nrf2 nuclear translocation and enhancing antioxidant effects. It inhibits IL-6 release with an IC50 of 4.816 µM. In a mouse model of PM2.5-induced lung injury, Nrf2 activator 18...
| MW: | 377.45 D |
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eGFP mRNA-LNP (500ng/uL)
Item number: TGM-T203248-10mg
Description: eGFP mRNA-LNP (500 ng/uL) is a lipid nanoparticle (LNP) containing eGFP mRNA, suitable for assays of RNA delivery, translation efficiency, and cell viability. eGFP circRNA includes the Enhanced Green Fluorescent Protein (eGFP), which expresses green fluorescent protein upon entering cells. eGFP is...
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Cyanine 3.5 bromide
Item number: TGM-T203286-10mg
Description: Cyanine 3.5 bromide (Cy3.5 NHS ester bromide) is an analog of the Cy3.5 fluorophore. This compound is a red fluorescent dye that actively labels amino groups in peptides, proteins, and oligonucleotides, with excitation and emission wavelengths of 591 nm and 604 nm, respectively. Target: Others
| Keywords: | Cy 3.5 bromide , Cy3.5 NHS ester bromide |
| MW: | 734.72 D |
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JCS-1
Item number: TGM-T203316-10mg
Description: JCS-1 is a potent DcpSPROTAC degrader. It non-covalently binds to DcpS via an RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 facilitates the ubiquitination and degradation of DcpS at nanomolar concentrations, with a DC50 of 87 nM in MOLM-14 cells. This compound can be utilized in research on...
| MW: | 1174.41 D |
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OICR41114
Item number: TGM-T203318-10mg
Description: OICR41114 (PROTAC4) is a PROTAC degrader targeting WDR5. It effectively degrades endogenous WDR5 with an EC50 of 40 nM and a Dmax of 49%. The degradation of HiBiT-tagged WDR5 by OICR41114 occurs in a proteasome-dependent manner. This compound is composed of a target protein ligand,...
| MW: | 1475.36 D |
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