Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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Janelia Fluor(R)646b, Maleimide
Item number: TGM-T87962-100mg
Description: Janelia Fluor(R)646b, Maleimide, is a blinking red fluorescent dye equipped with a maleimide group that allows for conjugation through thiol reactivity. Target: Others. Smiles: O=C1C=CC(=O)N1CCNC(=O)C=2C=CC(=C(C2)C=3C=4C=CC(=CC4[Si](C5=CC(C=CC53)=[N+]6CCC6)(C)C)N7CCC7)CO
| MW: | 604.78 D |
From 1,867.00€
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FX12
Item number: TGM-T87967-100mg
Description: FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD. Smiles: O=C(OC)C1=CC=2C=CC=CC2S1(=O)=O
| MW: | 224.23 D |
From 1,440.00€
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(S)-BI 2536
Item number: TGM-T87968-100mg
Description: (S)-BI 2536 serves as a dual inhibitor, targeting both PLK1 kinase and the BRD4 bromodomain, with Ki values of 0.42 nM and 54 nM, respectively. It is recognized as the less active enantiomer of BI 2536. Smiles: C(C)[C@@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C(C(NC4CCN(C)CC4)=O)C=C3)N2)C5CCCC5
| MW: | 521.65 D |
From 1,440.00€
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ELOVL6-IN-5
Item number: TGM-T87973-100mg
Description: ELOVL6-IN-5 (compound B) acts as an inhibitor targeting the elongase enzyme of the long-chain fatty acid family 6 (ELOVL6). This enzyme is pivotal in the elongation process of saturated and monounsaturated long-chain fatty acids, marking it as a strategic target for diabetes intervention. In a mouse...
| MW: | 439.45 D |
From 1,440.00€
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MJ04
Item number: TGM-T87974-100mg
Description: MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced...
| MW: | 345.37 D |
From 1,440.00€
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NSC80734
Item number: TGM-T87977-100mg
Description: NSC80734 is an IL-18 inhibitor that disrupts the interaction between human IL-18 and arthropod virus IL-18 binding protein (IL-18BP). It also suppresses the production of IFN-gamma induced by IL-18. Target: Interleukin. Smiles: N#CC1=CC=C(C=C1)NC(=O)NC2=CC=C(OC3=CC=C(C=C3)NC(=O)NC4=CC=C(C#N)C=C4)C=C2
| MW: | 488.5 D |
From 1,440.00€
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TEAD ligand 1
Item number: TGM-T87978-10mg
Description: TEAD ligand 1 is a ligand for the target protein TEAD. TEAD ligand 1 can be utilized in the synthesis of the PROTACTEAD degrader-1. Target: YAP, Ligands for Target Protein for PROTAC. Smiles: C(N[C@@H](C)C=1N=C(Br)C=CC1)(=O)C2=CC3=C(C(=CC=C3)C4=CC=C(C(F)(F)F)C=C4)C=C2
| MW: | 499.32 D |
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EE-Flipper 33
Item number: TGM-T87979-100mg
Description: EE-Flipper 33, a probe developed for investigating the early endocytosis mechanism, features a pKa of 10.6 and can track about 70% of early endosomes (EE) in live cells. Additionally, it labels the Golgi apparatus in live cells when the internal pH falls between 6.0 and 6.7. Target: Others. Smiles:...
| MW: | 714 D |
From 2,437.00€
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G-5758
Item number: TGM-T87983-100mg
Description: G-5758 is an orally active IRE1alpha inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown....
| MW: | 588.58 D |
From 1,668.00€
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TEAD-IN-11
Item number: TGM-T87984-100mg
Description: TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1 (IC 50 = 8.7 nM), TEAD2 (IC 50 = 3.4 nM), and TEAD3 (IC 50 = 5.6 nM), demonstrating selectivity for these isoforms as a covalent inhibitor. This compound is valuable for cancer research. Target: YAP. Smiles:...
| MW: | 293.28 D |
From 1,440.00€
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Myosin modulator 1
Item number: TGM-T87985-100mg
Description: Myosinmodulator 1 (Compound B141) is a myosin regulator that inhibits ATPase activity in rabbit psoas, porcine atrial, and porcine ventricular tissues, with IC25 values of 0.42, 0.13, and 3.09 µM, respectively. It also modulates cardiac contraction in Sprague Dawley rats. Target: Myosin. Smiles:...
| MW: | 389.33 D |
From 2,010.00€
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Myosin modulator 2
Item number: TGM-T87989-100mg
Description: Myosinmodulator 2 (Compound B172) is a myosin modulator that can inhibit ATPase activity in rabbit psoas muscle, pig atrium, and pig ventricle with IC25 values of 2.013, 2.94, and 20.93 µM, respectively. Additionally, Myosinmodulator 2 influences cardiac contractility in Sprague Dawley rats. Target:...
| MW: | 353.35 D |
From 1,858.00€
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