MJ04

Description: MJ04 is a selective inhibitor of Janus Kinase 3 (JAK3) with an IC50 of 2.03 nM. It hinders T cell differentiation and suppresses pro-inflammatory cytokines in macrophages induced by Lipopolysaccharides. In mice, MJ04 exhibits favorable pharmacokinetic properties and promotes hair growth in a DHT-induced alopecia model in athymic mice, without notable toxicity (LD50>2 g/kg). Target: IGF-1R, JAK, GSK-3, PI3K, EGFR. Smiles: FC=1C=CC(=CC1)C2=CN=C3NC=C(C=4N=C(N=CC4)NC5CC5)C3=C2