Products from TargetMol
TargetMol, based in Boston, Massachusetts, was founded in 2015 and is a drug screening expert in the life science community. The company offers diverse compound libraries, including FDA-approved libraries, and covers a broad spectrum of small molecule compounds such as inhibitors and agonists as well as recombinant proteins and natural products. TargetMol's products are used by researchers worldwide in areas such as cancer research, neurobiology, inflammation, immunology and metabolism.
More information at: www.targetmol.com
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MOR agonist-4
Item number: TGM-T88888-10mg
Description: MOR agonist-4 (2d), having an EC50 of 11 nM, is a G protein-biased agonist of the Kappa opioid receptor (KOR). This compound features a triazole-based, electron-withdrawing CF3 group and a bias factor of 38. MOR agonist-4 is utilized for antipruritic and analgesic applications. Target: Opioid Receptor
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SARS-CoV-2-IN-91
Item number: TGM-T88889-10mg
Description: SARS-CoV-2-IN-91 (Compound 194) is an inhibitor of SARS-CoV-2, exhibiting an EC50 of 28.92 µM. It inhibits the viruss -1 programmed ribosomal frameshifting (-1PRF) element, thereby suppressing the replication of SARS-CoV2. Target: SARS-CoV
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LSD1-IN-33
Item number: TGM-T88907-10mg
Description: LSD1-IN-33 (7d) is an orally effective inhibitor of LSD1, exhibiting an IC50 of 4.51 nM. It alleviates the activation of NRCFs induced by Ang II and reduces pathological cardiac hypertrophy and heart failure due to TAC-induced cardiac remodeling. Target: Histone Demethylase
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JMV7048
Item number: TGM-T88908-10mg
Description: JMV7048 is an effective PROTAC degrader targeting the PXR (Pregnane X Receptor), with a DC50 of 379 nM. It induces the polyubiquitination and degradation of PXR protein by recruiting the E3 CRBN ubiquitin ligase and the 26S proteasome. This degradation of PXR significantly enhances the chemosensitivity...
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NAT1-IN-1
Item number: TGM-T88910-10mg
Description: NAT1-IN-1 (compound 350) is a potent inhibitor targeting N-acetyltransferase 1 (NAT1), with an IC50 of 44 nM. It is applicable in the study of diseases characterized by metabolic hyperactivity, such as amyotrophic lateral sclerosis, cancer cachexia, and sepsis. Target: Histone Acetyltransferase
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AChE-IN-66
Item number: TGM-T88912-10mg
Description: Nematicidal Agent 1 is an effective nematicide that binds to the pocket of acetylcholinesterase (AChE). Target: Parasite
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SDH-IN-17
Item number: TGM-T88917-10mg
Description: SDH-IN-17 (compound C32) is a flavonol derivative containing an acylhydrazone, serving as an effective succinate dehydrogenase (SDH) inhibitor with an IC50 of 8.42 µM. This compound can bind to the active site and form strong interactions with key residues of SDH. Additionally, it exhibits antifungal...
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NO-IN-1
Item number: TGM-T88918-10mg
Description: NO-IN-1 (Compound 7a) inhibits the production of NO with an IC50 of 3.13 µM and displays anti-inflammatory properties. It acts by downregulating the expression of COX-2 and iNOS through the inhibition of the NF-kappaB signaling pathway. Target: NO Synthase, NF-kappaB, COX
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Succinate dehydrogenase-IN-3
Item number: TGM-T88964-10mg
Description: Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of succinate dehydrogenase (SDH) with antifungal activity. Target: Antifungal
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Endosidine 5
Item number: TGM-T88969-10mg
Description: Endosidine 5 (ES5) inhibits the secretion of EPS (extracellular polymeric substances) and cell wall expansion. It modifies the secretion of ECM (extracellular matrix) materials in Penium margaritaceum by affecting the Golgi apparatus. Additionally, Endosidine 5 disrupts endosomal cycling through Annexin...
| Keywords: | ES5 |
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Galectin-8N-IN-2
Item number: TGM-T88970-10mg
Description: Galectin-8N-IN-2 (compound 2) is an effective selective inhibitor of Galectin-8N, with a Ki value of 74 µM. Target: Galectin
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EGFR-IN-120
Item number: TGM-T88976-10mg
Description: EGFR-IN-120 (Compound 11eg) is an orally effective EGFR inhibitor. It exhibits potency against the EGFR L858R/T790M/C797S mutant with an IC50 of 0.053 µM, and displays weaker activity against EGFRWT, with an IC50 of 1.05 µM. EGFR-IN-120 inhibits the phosphorylation of EGFR as well as key downstream...
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