EGFR-IN-120

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T88976-10mg	10 mg	-	-	-	7 - 10 business days*		-
TGM-T88976-50mg	50 mg	-	-	-	7 - 10 business days*		-

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Description: EGFR-IN-120 (Compound 11eg) is an orally effective EGFR inhibitor. It exhibits... more

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Product information "EGFR-IN-120"

Description: EGFR-IN-120 (Compound 11eg) is an orally effective EGFR inhibitor. It exhibits potency against the EGFR L858R/T790M/C797S mutant with an IC50 of 0.053 µM, and displays weaker activity against EGFRWT, with an IC50 of 1.05 µM. EGFR-IN-120 inhibits the phosphorylation of EGFR as well as key downstream effectors including STAT3, AKT, and Erk. This compound induces cell cycle arrest and apoptosis in cells harboring the EGFR mutation. Additionally, EGFR-IN-120 inhibits the proliferation of NSCLC cells containing the EGFR L858R/T790M/C797S mutation, with an IC50 value of 0.052 µM. Target: EGFR, Akt, ERK, Apoptosis