JMV7048

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
TGM-T88908-10mg	10 mg	-	-	-	7 - 10 business days*		-
TGM-T88908-50mg	50 mg	-	-	-	7 - 10 business days*		-

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Description: JMV7048 is an effective PROTAC degrader targeting the PXR (Pregnane X Receptor),... more

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Product information "JMV7048"

Description: JMV7048 is an effective PROTAC degrader targeting the PXR (Pregnane X Receptor), with a DC50 of 379 nM. It induces the polyubiquitination and degradation of PXR protein by recruiting the E3 CRBN ubiquitin ligase and the 26S proteasome. This degradation of PXR significantly enhances the chemosensitivity of colorectal cancer stem cells, substantially delaying cancer recurrence in vivo. The composition of JMV7048 includes the PXR agonist JMV6944, a linker, and Thalidomide 5-fluoride. Target: PROTACs