32 products were found matching "K16817"!

Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and...

Description: Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids...

Description: LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT). Target: Phospholipase. Smiles: FC(F)(F)c1ccc(Oc2ccc(CCNC(=O)C(=O)CCCc3ccccc3)cc2)nc1....

Product Description: Phospholipase A and acyltransferase 3 (PLAAT3) is a member of the PLAAT family of enzymes, which are involved in the formation of N-acylphosphatidylethanolamines (NAPEs) and N-acyl ethanolamines (NAEs), important bioactive lipids with roles in anti-inflammation, fat catabolism, and...

Product Description: Phospholipase A and acyltransferase 3 (PLAAT3) is a member of the PLAAT family of enzymes, which are involved in the formation of N-acylphosphatidylethanolamines (NAPEs) and N-acyl ethanolamines (NAEs), important bioactive lipids with roles in anti-inflammation, fat catabolism, and...

Product Description: Phospholipase A and acyltransferase 3 (PLAAT3) is a member of the PLAAT family of enzymes, which are involved in the formation of N-acylphosphatidylethanolamines (NAPEs) and N-acyl ethanolamines (NAEs), important bioactive lipids with roles in anti-inflammation, fat catabolism, and...

Description: Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids...

LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2, IC50 = 100 nM). It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT, IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 µM) decreases arachidonic acid...

The HRAS like-suppressor 3 (HRASLS3) belongs to a class II tumor suppressor gene family and is involved in the regulation of differentiation and survival. This protein is expressed in several human tumors including ovarian carcinomas, lung carcinomas and may be involved in interferon-dependent cell death....

PLA2G16 specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. It also has a weak lysophospholipase activity (By similarity). Tumor suppressor that may be involved in interferon-dependent cell death. Applications: Suitable for use in Western Blot, Flow Cytometry, ELISA, Recommended...

PLA2G16 (Group 16 phospholipase A2, also HREV107 and AdPLA) is a Ca++-dependent 17-18kD member of the H-rev107 family of molecules. It is expressed intracellularly by white adipocytes, induced by insulin, and generates arachadonic acid from phospholipids. The arachadonic acid is converted to PGE2, which binds the...

Human PLA2G16 Recombinant Protein (RPES0096) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications Protein function: Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:19047760, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows...