LEI-110

LEI-110 is an inhibitor of adipose phospholipase A2 (AdPLA2, IC50 = 100 nM). It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT, IC50s = 158, 158, and 25 nM, respectively). LEI-110 (10 µM) decreases arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) levels in U2OS cells expressing human AdPLA2 and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.Formal Name: alpha-oxo-N-[2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]ethyl]-benzenepentanamide. CAS Number: 2313525-90-3. Molecular Formula: C25H23F3N2O3. Formula Weight: 456.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: soluble. SMILES: O=C(C(CCCC1=CC=CC=C1)=O)NCCC2=CC=C(C=C2)OC3=CC=C(C(F)(F)F)C=N3. InChi Code: InChI=1S/C25H23F3N2O3/c26-25(27,28)20-11-14-23(30-17-20)33-21-12-9-19(10-13-21)15-16-29-24(32)22(31)8-4-7-18-5-2-1-3-6-18/h1-3,5-6,9-14,17H,4,7-8,15-16H2,(H,29,32). InChi Key: DZHZISUSQMPBJQ-UHFFFAOYSA-N.