Androgen Receptor Ligand 3

Androgen receptor ligand 3 is an estrogen receptor (ER) ligand (KD = 0.39 µM in a radioligand binding assay) and an oxime derivative of estrone (Cay-10006485). Androgen receptor ligand 3 has been used in the synthesis of a specific and nongenetic IAP-dependent protein eraser (SNIPER) that decreases ERalpha levels in HT-1080 fibrosarcoma cells. Biotin conjugates of androgen receptor ligand 3 have been used in yeast three-hybrid systems.. SMILES: C[C@@]12[C@](CC/C2=N\OCC(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C=C4CC3. InChi Code: InChI=1S/C20H25NO4/c1-20-9-8-15-14-5-3-13(22)10-12(14)2-4-16(15)17(20)6-7-18(20)21-25-11-19(23)24/h3,5,10,15-17,22H,2,4,6-9,11H2,1H3,(H,23,24)/b21-18+/t15-,16-,17+,20+/m1/s1. InChi Key: UZKYYNQEKCAXLJ-YBFXVWRFSA-N