Imlunestrant
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Larger quantity required? Request bulk
A selective estrogen receptor degrader, induces degradation of wild-type ERalpha and ERalphaY537S... more
Product information "Imlunestrant"
A selective estrogen receptor degrader, induces degradation of wild-type ERalpha and ERalphaY537S at 100 nM, reduces growth of ER+ T47D and MCF-7 cells (IC50s = 0.34 and 5.2 nM, respectively) but not MDA-MB-231 cells, reduces growth of ERalphaY537S -expressing T47D and MCF-7 cells (IC50s = 113 and 512 nM, respectively), induces tumor regression in an ERbeta-independent, ERalpha-Y537S -mutant-harboring liver metastasis PDX model. SMILES: FC(F)(C1=CC=C(C2=CN=C3C(C=CC(O)=C3)=C42)C(O[C@@H]4C5=CC=C(OCCN6CC(C6)CF)C=C5)=C1)F. InChi Code: InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m1/s1. InChi Key: UVBQMXOKKDCBJN-MUUNZHRXSA-N
| Keywords: | (5R)-5-[4-[2-[3-(fluoromethyl)-1-azetidinyl]ethoxy]phenyl]-8-(trifluoromethyl)-H-[1]benzopyrano[4,3-c]quinolin-2-ol |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 44974 |
Properties
| Application: | Selective estrogen receptor degrader (SERD) |
| MW: | 524.52 D |
| Formula: | C29H24F4N2O3 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2408840-26-4| Matching products |
| KEGG ID : | K08550 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H351, H360, H400, H410 |
| P Phrases: | P201, P202, P273, P280, P308+313, P391, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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