34 products were found matching "K07211"!

CAY10576 is a multi-kinase inhibitor. It inhibits TANK-binding kinase 1 (TBK1), polo-like kinase 1 (Plk1), and IKKbeta (IC50s =0.093, 0.63, and 0.79 µM, respectively) and is selective for these kinases over IKKepsilon, Aurora B kinase, and cyclin-dependent kinase 2 (Cdk2, IC50s = 5, >5.32 and >30 µM, respectively)....

CAY10575 inhibits IKKbeta and polo-like kinase 1 (Plk1, IC50s = 0.075 and 0.125 µM, respectively). It also inhibits IKKepsilon (IC50 = 95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1mg/mL, DMSO: 10mg/mL, DMSO:PBS(7.2pH) 1:4: 0.2mg/mL. lambdamax: 295 nm. SMILES:...

MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKepsilon, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs, IC50s = 250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively)....

BAY-985 is a dual inhibitor of TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon, IC50 = 2 nM for both). It is selective for TBK1 and IKKepsilon over FLT3, RSK4, DRAK1, and ULK1 (IC50s = 123, 276, 311, and 7,390 nM, respectively). BAY-985 inhibits phosphorylation of interferon regulatory factor 3...

Protein function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells,...

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines Protein function:...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death (By...

Protein function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA...

Protein function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA...

Ikke is a member of the IKK (IKappaB kinase) family that has been identified as an oncogenic protein and found to be up-regulated in breast cancer, ovarian cancer and prostate cancer. The Ikke protein has 33% and 31% identity at the amino acid level with Ikka and Ikkb, respectively and is primarily activated by...