34 products were found matching "K05217"!

alpha,beta-Methyleneadenosine 5'-triphosphate (alphabeta-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the alpha- and beta-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 µM) and is ~1,000-fold...

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 µM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells...

A-317491 is a non-nucleotide antagonist of the purinergic receptors P2X3 and P2X2/3 (Kis = 22-92 nM in a calcium influx assay) that is selective over other purinergic and neurotransmitter receptors, ion channels, and enzymes (IC50s = >10 µM). It reduces thermal hyperalgesia induced by complete Freund's adjuvant in...

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary...

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary...

RO-3 is a dual antagonist of the purinergic receptor subtypes P2X3 and P2X2/3 (IC50s = 0.1 and 1.26 µM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 receptors (IC50s = >10 µM for all) but is an antagonist of ML1-type melatonin receptors (IC50 = 0.398 µM).Formal Name:...

Protein function: Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as...

TNP-ATP is a derivative of ATP and an antagonist of the purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50s = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing the human receptors). It is selective for these receptors over the purinergic P2X2, P2X4, and P2X7 receptors (IC50s = 2, 15.2, and >30 µM,...

Gefapixant is an allosteric antagonist of the purinergic P2X3 receptor. It inhibits agonist-induced P2X3 and P2X2/3 currents in 1321N1 cells co-expressing human P2X2 and P2X3 (IC50s = 153 and 220 nM, respectively) but does not inhibit P2X2 currents in the same cells at 10 µM. In vivo, gefapixant (30 mg/kg) increases...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

Host Species: Rabbit. Isotype: IgG. Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antigen affinity purification. Target Name: P2RX3. Antigen Species: Human

Description: Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Target: P2X Receptor. Smiles: COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(N)(=O)=O. References: Ford AP, In pursuit of P2X3 antagonists: novel...