Retigabine (hydrochloride)

Retigabine (Cay-39309) is an analytical reference standard categorized as a positive allosteric modulator (PAM) of KCNQ2-5 (Kv7.2-7.5) potassium ion channels. Formulations containing retigabine have been used in the treatment of partial epilepsies. Retigabine is regulated as a Schedule V compound in the United States. This product is intended for research and forensic applications.Formal Name: N-[2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]-carbamic acid, ethyl ester, dihydrochloride. CAS Number: 150812-13-8. Molecular Formula: C16H18FN3O2 . 2HCl. Formula Weight: 376.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 10 mg/ml. lambdamax: 259 nm. SMILES: O=C(OCC)NC1=C(N)C=C(NCC2=CC=C(F)C=C2)C=C1.Cl.Cl. InChi Code: InChI=1S/C16H18FN3O2.2ClH/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11,,/h3-9,19H,2,10,18H2,1H3,(H,20,21),2*1H. InChi Key: WSGFOWNASITQHJ-UHFFFAOYSA-N.