44 products were found matching "K04174"!

An APJ agonist, inhibits forskolin-induced cAMP accumulation in CHO cells expressing human APJ (EC50 = 0.23 nM), increases stroke volume and heart rate and decreases systemic vascular resistance, indicating increased cardiac reserve, in ZSF1 obese rats in a model of diastolic dysfunction at 1 mg/kg, i.v.. SMILES:...

Recombinant CHO-K1 cells stably overexpress human apelin receptor (AGTRL1) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Cay-13524), apelin-17, and apelin-13 (Cay-13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50...

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM (the...

MM-54 is a peptide antagonist of the apelin receptor (APJ, Ki = 82 nM). It inhibits apelin-13-induced increases in number of stem cells and tumorspheres and the percentage of cells with aldehyde dehydrogenase (ALDH) activity, a marker of stem cells, in patient-derived glioblastoma spheroids when used at a...

The apelin receptor (APJ) signaling pathway mediates cardiovascular homeostasis and is involved in the pathogenesis of cardiovascular diseases. ML-233 is a novel APJ agonist (EC50 = 3.7 µM) that is >21-fold selective over the closely related angiotensin 1 receptor (EC50 = >79 µM).Formal Name:...

ML-221 is an antagonist of the G protein-coupled receptor (GPCR) APJ (IC50 = 4.8 µM). It is selective for APJ over the angiotensin II type 1 (AT1) receptor (IC50 = >78 µM). ML-221 antagonizes apelin 13-induced activation of APJ in cAMP and beta-arrestin recruitment assays (IC50s = 0.7 and 1.75 µM, respectively). It...

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive...

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive...

Protein function: Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human APLNR. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human APLNR. Next,...

Organism: Mus musculus (Mouse). Source: E.coli. Expression Region: 307-377aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: YAFFDPRFRQ ACTSMLCCDQ SGCKGTPHSS SAEKSASYSS GHSQGPGPNM GKGGEQMHEK SIPYSQETLV D. Purity: Greater than 85% as determined by...