ML-233

The apelin receptor (APJ) signaling pathway mediates cardiovascular homeostasis and is involved in the pathogenesis of cardiovascular diseases. ML-233 is a novel APJ agonist (EC50 = 3.7 µM) that is >21-fold selective over the closely related angiotensin 1 receptor (EC50 = >79 µM).Formal Name: (E)-4-methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one. Synonyms: CID-46905036. Molecular Formula: C19H21NO4S. Formula Weight: 359.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml. lambdamax: 219, 286 nm. SMILES: CC(/C(C=C1C2CCCCC2)=N/OS(=O)(C3=CC=CC=C3)=O)=CC1=O. InChi Code: InChI=1S/C19H21NO4S/c1-14-12-19(21)17(15-8-4-2-5-9-15)13-18(14)20-24-25(22,23)16-10-6-3-7-11-16/h3,6-7,10-13,15H,2,4-5,8-9H2,1H3/b20-18+. InChi Key: RSMZOLWJZGIWOV-CZIZESTLSA-N.