70 products were found matching "K04143"!

Mirabegron is an agonist of the beta3-adrenergic receptor (beta3-AR). It induces cAMP accumulation in CHO cells expressing the beta3-AR but not the beta1- or beta2-AR (EC50s = 0.0224, >10, and >10 µM, respectively). Mirabegron reduces contraction induced by carbamoylcholine (Cay-14486) of isolated rat and human...

L-755,507 is a partial agonist of beta3-adrenergic receptors (EC50 = 0.43 nM). It displays more than 440-fold selectivity for beta3- over beta1- and beta2-adrenoceptors (EC50s = 580 and >10,000 nM, respectively). At 5 µM, this compound has been used to enhance CRISPR-mediated homology-directed repair efficiency by...

A beta-adrenergic agonist.

CL 316,243 is a beta3-adrenoceptor agonist (EC50 = 3 nM) that is >10,000-fold selective over beta1 and beta2. It causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity.Formal Name:...

SR 59230A (hydrochloride) is a beta3-adrenergic receptor (beta3-AR) antagonist (pA2s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively). It is less selective for beta3-AR in cells transfected with the human beta-AR subtypes (Kis = 16.4, 61.9, and 122 nM for beta1-,...

SR 58611A is a selective beta3-adrenergic receptor agonist (beta3-AR, EC50 = 3.5 nM in rat colon). Its activity cannot be blocked by the beta1- and beta2-AR antagonists CGP 20712A and ICI 118551 (Cay-15591), respectively. SR 58611A is minimally active against beta1-ARs in rat uterus (EC50 = 499 nM) and inactive...

Alprenolol is a non-selective beta-adrenergic receptor (beta-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. It binds to beta1-, beta2-, and beta3-ARs expressed in CHO cells (Kds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT1A and...

Levobunolol (hydrochloride) is a beta-adrenergic antagonist that acts as a vasodilator and increases ocular circulation when applied in solution to the eye. Topical formulations containing levobunolol are used to manage glaucoma.Formal Name:...

BRL 37344 is a selective agonist of beta3-adrenergic receptors with Ki values of 0.43, 9.17, and 37.9 µM for beta3, beta2, and beta1, respectively. beta3-Adrenoceptors are expressed in adipose tissue as well as endothelial and myocardial tissues. This compound has been used to explore the role of these receptors in...

L-748,337 is a beta3-adrenergic receptor antagonist that displays selectivity over beta1 and beta2 receptors (Kis = 4, 390, and 204 nM, respectively). It has been shown to couple with Gi to activate MAPK signaling. L-748,337 can inhibit agonist-stimulated lipolysis in rhesus monkey adipocytes, as well as...

Penbutolol is an antagonist of beta-adrenergic receptors (beta-ARs, IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM). It inhibits adenylate cyclase activity induced by the beta-AR agonist isoprenaline (isoproterenol, Cay-15592) in guinea pig myocardial membranes with a Ki value of 2.4...

Protein function: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. [The UniProt Consortium]