Penbutolol (hemisulfate)

Penbutolol is an antagonist of beta-adrenergic receptors (beta-ARs, IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM). It inhibits adenylate cyclase activity induced by the beta-AR agonist isoprenaline (isoproterenol, Cay-15592) in guinea pig myocardial membranes with a Ki value of 2.4 nM. Penbutolol reduces basal renin activity and blood pressure in spontaneously hypertonic rats. It decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses reductions in aggression induced by 8-hydroxy-DPAT (Cay-22608) and TFMPP with ED50 values of 8.1 and 2.1 µmol/kg, respectively. Formulations containing penbutolol were previously used in the treatment of arterial hypertension.Formal Name: (2S)-1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol, hemisulfate. CAS Number: 38363-32-5. Synonyms: HOE 39-893d. Molecular Formula: C18H29NO2 . 1/2H2SO4. Formula Weight: 340.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 0.25 mg/ml. lambdamax: 217 nm. SMILES: O[C@@H](CNC(C)(C)C)COC1=C(C2CCCC2)C=CC=C1.O=S(O)(O)=O.O[C@@H](CNC(C)(C)C)COC3=C(C4CCCC4)C=CC=C3. InChi Code: InChI=1S/2C18H29NO2.H2O4S/c2*1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14,1-5(2,3)4/h2*6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3,(H2,1,2,3,4)/t2*15-,/m00./s1. InChi Key: FEDSNBHHWZEYTP-ZFQYHYQMSA-N.