Alprenolol

Alprenolol is a non-selective beta-adrenergic receptor (beta-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. It binds to beta1-, beta2-, and beta3-ARs expressed in CHO cells (Kds = 15, 0.91, and 117 nM, respectively, for the human receptors) and to 5-HT1A and 5-HT1B receptors in rat hippocampal and striatal membranes (Kis = 34 and 134 nM, respectively). In vivo, alprenolol (40 mg/kg, i.v.) completely blocks the hyperactivity response of rats to 2-PCPA (Cay-10010494) and L-tryptophan. Alprenolol (10 µg, i.v.) inhibits decreases in heart rate and left ventricular systolic pressure induced by the beta2-AR antagonist ICI 118551 (Cay-15591) in transgenic mice overexpressing the beta2-AR. It also reduces the level of abnormal prion fibrils (PrPSc) in the brain of mice intracerebrally infected with prion disease to less than 20% of control levels when administered in drinking water at a dose of 50 mg/L.Formal Name: 1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-2-propanol. CAS Number: 13655-52-2. Synonyms: (±)-Alprenolol, dl-Alprenolol, (RS)-Alprenolol. Molecular Formula: C15H23NO2. Formula Weight: 249.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 218, 272 nm. SMILES: C=CCC1=C(OCC(CNC(C)C)O)C=CC=C1. InChi Code: InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3. InChi Key: PAZJSJFMUHDSTF-UHFFFAOYSA-N.