Lisaftoclax

A Bcl-2 inhibitor (Ki = 50s = 0.014-0.384 µM) over those with low Bcl-2 and high Mcl-1 expression (IC50s = 1.11-10.343 µM), induces apoptosis in OCI-LY8 and OCI-Ly19 cells at 5, 10, and 50 nM, induces M2-to-M1 repolarization in TAMs, reduces tumor growth in an OCI-LY8 DLBCL mouse xenograft model at 50 and 100 mg/kg, enhances anti-PD-1 monoclonal antibody-induced reductions in tumor growth in an H1299 humanized mouse model of NSCLC. SMILES: ClC(C=C1)=CC=C1C(CC2(CCC2)CC3)=C3CN4CCN(C5=CC(OC6=CN=C7NC=CC7=C6)=C(C(NS(C8=CC([N+]([O-])=O)=C(NC[C@@H]9OCCOC9)C=C8)(=O)=O)=O)C=C5)CC4. InChi Code: InChI=1S/C45H48ClN7O8S/c46-33-4-2-30(3-5-33)39-25-45(12-1-13-45)14-10-32(39)28-51-16-18-52(19-17-51)34-6-8-38(42(23-34)61-35-22-31-11-15-47-43(31)49-26-35)44(54)50-62(57,58)37-7-9-40(41(24-37)53(55)56)48-27-36-29-59-20-21-60-36/h2-9,11,15,22-24,26,36,48H,1,10,12-14,16-21,25,27-29H2,(H,47,49)(H,50,54)/t36-/m0/s1. InChi Key: FNBXDBIYRAPDPI-BHVANESWSA-N