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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| BPS-100972 | 10 µg | - | - |
3 - 15 business days* |
883.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Serine/threonine kinase which plays an important role in the regulation of... more
Product information "WNK2, GST-Tag"
Protein function: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. [The UniProt Consortium]
| Keywords: | non-specific serine/threonine protein kinase, |
| Supplier: | BPS Bioscience |
| Supplier-Nr: | 100972 |
Properties
| Application: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Conjugate: | No |
| Host: | Insect cells |
| Species reactivity: | human |
| MW: | 100 kD |
Database Information
| KEGG ID : | K08867 | Matching products |
| UniProt ID : | E9PCD1 | Matching products |
| Gene ID | GeneID 65268 | Matching products |
Handling & Safety
| Storage: | -80°C |
| Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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