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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human recombinant sFas Receptor produced in E.coli is a single, non-glycosylated polypeptide... more
Product information "sFas Receptor, human recombinant (rHuFAS)"
Human recombinant sFas Receptor produced in E.coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 17.6kDa. Fas and Fas Ligand (FasL) are members of the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas initiates apoptosis in Fas-bearing cells. The apoptosis mechanism involves the recruitment of pro-caspase 8 through an adaptor molecule named FADD followed by processing of the pro-enzyme to active forms. These active caspases subsequently cleave a variety of cellular substrates leading to the eventual cell death. sFasR is able to inhibit FasL-induced apoptosis by acting as a decoy receptor whicht serves as a sink for FasL. The full length Fas Receptor is a 319 amino acids type I transmembrane protein, which contains a 157 amino acids extracellular domain, a 17 amino aicds transmembrane domain, and 145 amino acids cytoplasmic domain. The mature human Fas ECD shares 55%, 58%, a.a sequence identity with the mouse, rat, Fas, respectively.
Keywords: | Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6. |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97567 |
Properties
Application: | Cell Culture |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 17600 D |
Purity: | >95% |
Format: | Lyophilized |
Database Information
KEGG ID : | K04390 | Matching products |
UniProt ID : | P25445 | Matching products |
Gene ID | GeneID 355 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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