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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSR030466.10 | 10 µg | - |
7 - 16 business days* |
261.00€
|
|||
E-PKSR030466.50 | 50 µg | - |
7 - 16 business days* |
594.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NCBI Reference Sequence: YP_009725308.1. Recombinant 2019-nCoV Helicase is produced by our E.coli... more
Product information "SARS-CoV-2 (2019-nCoV) Helicase Protein (His Tag), recombinant"
NCBI Reference Sequence: YP_009725308.1. Recombinant 2019-nCoV Helicase is produced by our E.coli expression system and the target gene encoding Ala1-Gln601 is expressed with a 6His tag at the C-terminus. The non-structural protein 13 (nsp13) of SARS-CoV 2 is a helicase that separates double-stranded RNA or DNA with a 5'-3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5'-3' direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially, helicases were only thought to be molecular engines that unwind nucleic acids during replication, recombination, and DNA repair. Recent studies have shown that they are also involved in other biological processes, including displacement of proteins from nucleic acid, movement of Holliday junctions, chromatin remodeling, catalysis of nucleic acid conformational changes, several aspects of RNA metabolism, including transcription, mRNA splicing, mRNA export, translation, RNA stability and mitochondrial gene expression. Some human diseases, including Bloom's syndrome, Werner's syndrome, and Xeroderma Pigmentosum have been associated with defects in helicase function. Helicase, Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.
Keywords: | SARS-CoV 2 Helicase, SARS-CoV 2 nsp13 |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSR030466 |
Properties
Conjugate: | No |
Host: | E.coli |
Species reactivity: | SARS-CoV-2 |
MW: | 70 kD |
Purity: | > 90 % as determined by reducing SDS-PAGE. |
Format: | Solution |
Database Information
KEGG ID : | K24149 | Matching products |
UniProt ID : | P0DTD1 | Matching products |
Gene ID | GeneID 43740578 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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