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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-32-8083-10 | 10 µg | - | - |
3 - 11 business days* |
546.00€
|
||
ABE-32-8083-50 | 50 µg | - | - |
3 - 11 business days* |
979.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Source: E.coli. MW :31.3kD. Recombinant Human Toll-Interacting Protein is produced by our E.coli... more
Product information "Recombinant Human Toll-Interacting Protein/TOLLIP (C-6His)"
Source: E.coli. MW :31.3kD. Recombinant Human Toll-Interacting Protein is produced by our E.coli expression system and the target gene encoding Ala2-Pro274 is expressed with a 6His tag at the C-terminus. Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). The Toll-like receptors pathway is a part of the immune system that recognize structurally conserved molecular patterns of microbial pathogens, resulting in an inflammatory immune response. TOLLIP constitutes a complex with Tom1 to regulate endosomal transferring of ubiquitinated proteins. TOLLIP can negative regulate Toll-like receptors signaling, which may limit the production of proinflammatory mediators during the process of inflammation and infection. Protein function: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin- ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). [The UniProt Consortium]
Supplier: | Abeomics |
Supplier-Nr: | 32-8083 |
Properties
Conjugate: | No |
Database Information
KEGG ID : | K05402 | Matching products |
UniProt ID : | Q9H0E2 | Matching products |
Gene ID | GeneID 54472 | Matching products |
Handling & Safety
Storage: | +20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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