Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay11286-100 | 100 µg | - |
6 - 10 business days* |
465.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DNA methylation occurs mainly at the 5'-position of cytosine rings (5-methylcytosine (5mC)). The... more
Product information "MBD2 (human recombinant, methyl binding domain aa 150-220)"
DNA methylation occurs mainly at the 5'-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding domain 2 (MBD2) protein specifically binds to methylated promoters on CpG islands. The MBD protein family consists of five members: MeCP2, MBD1, MBD2, MBD3, and MBD4. The sequence similarity between the MBD proteins is limited to the MBD domains. MBD2 binding to 5mC facilitates the recruitment of chromatin remodeling and transcriptional repressor complexes, which results in a repressive chromatin state. MBD2 has been implicated in breast cancer progression. Silencing of MBD2 protein expression was found to be sufficient to initiate and maintain tumor suppressor gene transcription.Synonyms: Methyl-CpG Binding Domain Protein 2, Methyl Cytosine Binding Domain Protein 2. Purity: >95%. Source: Recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 150-220 (partial protein). MW: 34.8 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 7.5, with 500 mM sodium chloride, 5% glycerol, and 5 mM beta-mercaptoethanol. UniProt Accession #: Q9UBB5.
Keywords: | DMTase, DMTase, Demethylase, Demethylase, Methyl-CpG-binding protein MBD2, Methyl-CpG-binding protein MBD2, Methyl-CpG-binding domain protein 2, Methyl-CpG-binding domain protein 2 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 11286 |
Properties
Application: | Gene regulation studies |
Conjugate: | No |
Host: | E.coli |
MW: | 34,8 kD |
Purity: | >95% |
Format: | Solution |
Database Information
KEGG ID : | K11590 | Matching products |
UniProt ID : | Q9UBB5 | Matching products |
Gene ID | GeneID 8932 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H316, H373 |
P Phrases: | P260, P314, P332+313, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed