Jagged-2 (human):Fc (human, rec.)

Human Jagged-2 (amino acids 1-1054) is fused at the C-terminus to the Fc portion of human IgG. Liquid. 0.2µm-filtered solution in PBS. Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development