Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH032559.10 | 10 µg | - |
7 - 16 business days* |
73.00€
|
|||
E-PKSH032559.50 | 50 µg | - |
7 - 16 business days* |
152.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Construction: Recombinant Human Interleukin-1 Receptor Accessory Protein is produced by... more
Product information "IL-1 Receptor Accessory Protein/IL-1RAcP/IL-1R3 Protein(C-Fc-6His) (recombinant human)"
Protein Construction: Recombinant Human Interleukin-1 Receptor Accessory Protein is produced by our Mammalian expression system and the target gene encoding Ser21-Gln356 is expressed with a Fc, 6His tag at the C-terminus. Sequence: Ser21-Gln356. Fusion tag: C-Fc-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 82 kDa. Protein function: Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1a, IL1ßand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. In addition, IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor. Protein function: Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). [The UniProt Consortium]
Keywords: | IL1RAP, IL-1R3, C3orf13, IL-1R-3, IL-1RAcP, Interleukin-1 receptor 3, IL-1 receptor accessory protein, Interleukin-1 receptor accessory protein, Recombinant Human IL-1 Receptor Accessory Protein/IL-1RAcP/IL-1R3 Protein(C-Fc-6His) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH032559 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 39.7 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K04723 | Matching products |
UniProt ID : | Q9NPH3 | Matching products |
Gene ID | GeneID 3556 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed