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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay31819-100 | 100 µg | - |
6 - 10 business days* |
439.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme that catalyzes the conversion of... more
Product information "GAPDH (human, recombinant)"
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme that catalyzes the conversion of glyceraldehyde-3-phosphate (Cay-17865) to 1,3-bisphosphoglycerate during glycolysis and is involved in numerous additional cellular processes, including intracellular trafficking, receptor-mediated signaling, apoptosis, DNA repair, and the oxidative stress response. It exists as a tetramer and is composed of an N-terminal domain, which contains binding sites for NAD+, phosphatidylserine, RNA, and glutathione, and a C-terminal catalytic domain. GAPDH is widely expressed and primarily localizes to the cytosol, where it has roles in glycolysis and intracellular trafficking. It also localizes to the nucleus, mediating DNA integrity, gene transcription, and apoptosis, as well as to cellular membranes, where it has roles in membrane fusion and iron transport. GAPDH expression is increased by insulin, hypoxia-inducible factor-1 (HIF-1), p53, and nitric oxide (NO) and decreased by acetylated histones. Aberrant mRNA and protein levels of GAPDH have been found in tumor biopsies from patients with a variety of cancers, including lung, renal cell, colorectal, or breast cancer. Cayman's GAPDH (human, recombinant) protein consists of 346 amino acids and has a calculated molecular weight of 38 kDa.Synonyms: GAPD Protein, G3PD Protein, HEL-S-162eP, Peptidyl-cysteine S-nitrosylase. Purity: >90% estimated by SDS-PAGE. Source: Recombinant human N-terminal His-tagged GAPDH expressed in E. coli. Amino Acids: 1-335 (full length). MW: 38 kDa. Formulation: (Request formulation change), Lyophilized from sterile 50 mM Tris, pH 7.5, with 30% glycerol. UniProt Accession #: P04406.
Keywords: | GAPD, GAPDH, GAPDH, GAPDH, CDABP0047, Peptidyl-cysteine S-nitrosylase GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH, Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase |
Supplier: | Cayman Chemical |
Supplier-Nr: | 31819 |
Properties
Application: | SDS-PAGE |
Conjugate: | No |
Purity: | >90% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K00134 | Matching products |
UniProt ID : | P04406 | Matching products |
Gene ID | GeneID 2597 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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