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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10770-25 | 25 µg | - |
6 - 10 business days* |
732.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The DNA methyltransferase 3 (DNMT3) family of DNMT proteins establish intial methylation of... more
Product information "DNA Methyltransferase 3L (human recombinant)"
The DNA methyltransferase 3 (DNMT3) family of DNMT proteins establish intial methylation of cytosines to form 5-methylcytosine at CpG (cytosine-phosphate-guanine) sites. Once methylation is established on DNA, DNMT1 protein is responsible for maintaining the CpG methylation pattern during chromosome replication. The DNMT3 family includes the two active members, DNMT3a and DNMT3b, and the regulatory factor DNMT3-like protein (DNMT3L). DNMT3L contains a cysteine-rich, DNMT3/ATRX homology or ATRX-DNMT3-DNMT3L (ADD) domain, however it lacks the proline-tryptophan-tryptophan-proline (PWWP) domain, required for non-specific DNA binding. The ADD domain of DNMT3L is responsible for specifically binding to unmethylated histone H3 lysine 4 (H3K4me0). DNMT3L also lacks the conserved residues in the C-terminal DNA MTase domain of DNMT3a and 3b that are required for activity. However, DNMT3L is required to stimulate the DNA methylation activity of DNMT3a and 3b through interactions with the catalytic domain of DNMT3a and 3b.Synonyms: DNMT3L, DNMT3-Like Protein. Purity: >95% estimated by SDS-PAGE. Source: recombinant N-terminal GST-tagged protein expressed in E. coli. Amino Acids: 160-387 (N-terminal truncation). MW: 53.2 kDa. UniProt Accession #: Q9UJW3.
Keywords: | DNMT3L, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3-like |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10770 |
Properties
Application: | Methylation studies |
Conjugate: | No |
MW: | 53,2 kD |
Purity: | >95% estimated by SDS-PAGE |
Database Information
KEGG ID : | K17400 | Matching products |
UniProt ID : | Q9UJW3 | Matching products |
Gene ID | GeneID 29947 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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