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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH030690.50 | 50 µg | - |
7 - 16 business days* |
869.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl... more
Product information "Alkaline Phosphatase / ALPI Protein (His tag) (recombinant human)"
Activity: Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl phosphate (4-MUP).The specific activity is > 1,000 pmoles/min/µg. Protein Construction: A DNA sequence encoding the mature form of human ALPI (P09923) (Met 1-Asp 503),without the pro peptide, was fused with a polyhistidine tag at the C-terminus. Sequence: Met 1-Asp 503. Fusion tag: C-His Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method. Apparent Molecular Mass: 66 kDa. Protein function: ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders.
Keywords: | IAP, ALPI, EC=3.1.3.1, Intestinal alkaline phosphatase, Intestinal-type alkaline phosphatase, Recombinant Human Alkaline Phosphatase / ALPI Protein (His tag) |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH030690 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 54 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K01077 | Matching products |
UniProt ID : | P09923 | Matching products |
Gene ID | GeneID 248 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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