ssK36 (trifluoroacetate salt)

ssK36 is a peptide super-substrate for the histone methyltransferase SET domain-containing protein 2 (SETD2) corresponding to amino acids 29-43 of histone H3 lysine 36 (H3K36) with amino acid substitutions at positions 31, 32, 36, 37, and 39. ssK36 is methylated 70-fold more and 290-fold faster than H3K36 (29-43) in cell-free assays.Formal Name: (S)-2-(((S)-2-((6S,9S,18S, 21S,24S)-1- amino-6-(((S)- 2-((S)-3- amino-2- oxobutanoyl) pyrrolidin-1- yl)amino)-21- (4-amino butyl)-9- benzyl-24- (3-guanidino propyl)-1- imino-18- isopropyl-7, 10,13,16,19, 22,25-hepta oxo-2,8,11,14, 17,20,23-hepta azahexacosan- 26-oyl) pyrrolidin-1- yl)amino)-N1- ((6S,9S,12S)- 1,17-diamino- 9-(4-hydroxy benzyl)-6-(2- ((S)-1-hydroxy pyrrolidin- 2-yl)-2-oxo acetyl)-1,17- diimino-8,11- dioxo-2,7,10, 16-tetraaza heptadecan-12- yl)succinimide, trifluoroacetate salt. Molecular Formula: C79H127N29O18 . XCF3COOH. Formula Weight: 1771.1. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: APRFGGVKRPNRYRP-OH. Solubility: Water: soluble. SMILES: [H]N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)C.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C79H127N29O18.C2HF3O2/c1-43(2)62(105-61(112)42-95-60(111)41-96-63(113)53(38-45-16-5-4-6-17-45)102-66(116)50(20-10-32-92-77(85)86)98-69(119)56-23-13-35-106(56)72(122)44(3)81)71(121)99-48(18-7-8-30-80)64(114)100-51(21-11-33-93-78(87)88)73(123)107-36-14-24-57(107)70(120)104-55(40-59(82)110)68(118)97-49(19-9-31-91-76(83)84)65(115)103-54(39-46-26-28-47(109)29-27-46)67(117)101-52(22-12-34-94-79(89)90)74(124)108-37-15-25-58(108)75(125)126,3-2(4,5)1(6)7/h4-6,16-17,26-29,43-44,48-58,62,109H,7-15,18-25,30-42,80-81H2,1-3H3,(H2,82,110)(H,95,111)(H,96,113)(H,97,118)(H,98,119)(H,99,121)(H,100,114)(H,101,117)(H,102,116)(H,103,115)(H,104,120)(H,105,112)(H,125,126)(H4,83,84,91)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94),(H,6,7)/t44-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,62-,/m0./s1. InChi Key: LZBDFQHVTIOMGH-LZRCCSAXSA-N.