Furin Inhibitor I (trifluoroacetate salt)

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.Formal Name: N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-L-lysinamide, trifluoroacetate salt. Synonyms: Decanoyl-Arg-Val-Lys-Arg-CMK. Molecular Formula: C34H66ClN11O5 . XCF3COOH. Formula Weight: 744.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCC)=O)CCCNC(N)=N)=O)C(C)C)=O)CCCCN)N[C@@H](CCCNC(N)=N)C(CCl)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C34H66ClN11O5.C2HF3O2/c1-4-5-6-7-8-9-10-18-28(48)43-25(17-14-21-42-34(39)40)31(50)46-29(23(2)3)32(51)45-26(15-11-12-19-36)30(49)44-24(27(47)22-35)16-13-20-41-33(37)38,3-2(4,5)1(6)7/h23-26,29H,4-22,36H2,1-3H3,(H,43,48)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42),(H,6,7)/t24-,25-,26-,29-,/m0./s1. InChi Key: QYMXBIIZDOWKAX-AZRYXFGXSA-N.