Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2

Dnp-P-Cha-Abu-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.Formal Name: (S)-N-((7S,10S,13S,16R,19S,22S)-13-((1H-imidazol-5-yl)methyl)-7-carbamoyl-23-cyclohexyl-19-ethyl-10-methyl-1-(2-(methylamino)phenyl)-16-((methylthio)methyl)-1,9,12,15,18,21-hexaoxo-2,8,11,14,17,20-hexaazatricosan-22-yl)-1-(2,4-dinitrophenyl)pyrrolidine-2-carboxamide. Synonyms: Dnp-Pro-Cha-Abu-Cys(Me)-His-Ala-Lys(Nma)-NH2, Matrix Metalloproteinase-1 Fluorogenic Substrate III, MMP-1 Fluorogenic Substrate III. Molecular Formula: C51H72N14O12S. Formula Weight: 1105.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Formic Acid: 1 mg/ml. SMILES: NC([C@H](CCCCNC(C1=CC=CC=C1NC)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)CC4CCCCC4)=O)CC)=O)CSC)=O)CC5=CN=CN5)=O)C)=O)=O. InChi Code: InChI=1S/C51H72N14O12S/c1-5-35(58-49(71)38(24-31-14-7-6-8-15-31)61-51(73)42-19-13-23-63(42)41-21-20-33(64(74)75)26-43(41)65(76)77)47(69)62-40(28-78-4)50(72)60-39(25-32-27-54-29-56-32)48(70)57-30(2)45(67)59-37(44(52)66)18-11-12-22-55-46(68)34-16-9-10-17-36(34)53-3/h9-10,16-17,20-21,26-27,29-31,35,37-40,42,53H,5-8,11-15,18-19,22-25,28H2,1-4H3,(H2,52,66)(H,54,56)(H,55,68)(H,57,70)(H,58,71)(H,59,67)(H,60,72)(H,61,73)(H,62,69)/t30-,35-,37-,38-,39-,40-,42-/m0/s1. InChi Key: ZXWDGVAWRUKOAR-IHGWQQAUSA-N.