Amastatin . hydrochloride

White to off-white powder. Soluble in DMF, ethanol, DMSO or aqueous solvents (PBS). Slow, tight binding and competitive aminopeptidase (AP) inhibitor, Inhibits cytosolic leucine aminopeptidase, microsomal aminopeptidase M and bacterial leucine aminopeptidase,,human serum aminopeptidase A (AP-A), aminopeptidase N (AP-N), tyrosine aminopeptidase, but not aminopeptidase B (AP-B), Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin or thermolysin, Inhibits completely the Suc-Ala-Ala-Pro-Leu-pNA amidolytic enzyme, Slightly inhibits the formation of angiotensin III (Ang III) from Angiotensin II through AP-A, but significantly increases the potency of angiotensin III and [des-Asp1]-angiotensin I, Moderate inhibitor of mitochondrial intermediate peptidase (MIP), Weak inhibitor of simian immunodeficiency virus protease (SIV-PR).