Substrates and Inhibitors

The FMK peptides are potent, cell permeable, irreversible capase inhibitors. It is useful for detecting and monitoring apoptosis in vitro and in vivo applications. BOC-ASP(OMe)-FMK is the key intermediate for developing and preparing FMK-based capase inhibitors and probes. The Asp(OMe)-FMK-based caspase inhibitors...

The FMK peptides are potent, cell permeable, irreversible capase inhibitors. It is useful for detecting and monitoring apoptosis in vitro and in vivo applications. BOC-ASP(OMe)-FMK is the key intermediate for developing and preparing FMK-based capase inhibitors and probes. The Asp(OMe)-FMK-based caspase inhibitors...

Sequence (linear): Biotin-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product,...

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

Z-LETD-FMK is a cell permeable, irreversible caspase protease 8 inhibitor that binds to the catalytic site of caspase- 8, which plays an important role in the induction of apoptosis. The binding of Z-LETD-FMK to caspase-8 inhibits the activity of this protease, enabling it to inhibit apoptotic events associated with...

Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide spectrum of diseases. In late 2019, a novel coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was determined as a cause for several cases of respiratory disease (Covid-19). Even though most infected...

Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide spectrum of diseases. In late 2019, a novel coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was determined as a cause for several cases of respiratory disease (Covid-19). Even though most infected...

Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide spectrum of diseases. In late 2019, a novel coronavirus, termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was determined as a cause for several cases of respiratory disease (Covid-19). Even though most infected...

Molecular weight: 1145.15. Excitation (nm): 322. Emission (nm): 381. Correction factor (280 nm): 0.3. Mca-YVADAPK(Dnp)-OH is a fluorogenic peptide substrate for detecting caspase-1/interleukin-converting enzyme (ICE) and angiotensin I-converting enzyme-2 (ACE-2). Its N-terminal contains a highly fluorescent...

Molecular weight: 1638.96. Excitation (nm): 322. Emission (nm): 381. Correction factor (280 nm): 0.3. Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorogenic peptide substrate for detecting tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) and related enzymes such as ADAM8, ADAM9 and ADAM10. Its N-terminal contains a...

EGRCK labeled with biotin is prepared by the method of Williams, et al. (11). Tri-peptide chloromethylketones have been utilized extensively to irreversibly inhibit various serine proteases (1-5). Among the most common chloromethylketones are FPRCK (Phe-Pro-Arg-chloromethylketone), which is a rapid inhibitor of...

KTSAVLQ-Rhodamine110-y-Glu (Lys-Tyr-SerAla-Val-Leu-Glu-Rh110-y-Glu) is a Rhodamine110 labeled fluorogenic peptidyl substrate that can be hydrolyzed by 3CLpro (Mpro) (#SBB-DE0129) a chemotrypsin-like protease, cleaving between the glutamine and the Rhodamine110 fluorophore. Prior hydrolysis, the Rhodamine110 moiety...