Urotensin II (goby) (trifluoroacetate salt)

Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki = 2.06 nM for the human recombinant receptor expressed in HEK293 cells). It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM. Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across isolated goby posterior intestine in 5% seawater-adapted solution. In vivo, urotensin II (1.5-150 nmol/kg) decreases diastolic blood pressure and increases heart rate in anesthetized rats. It also reduces the pressor responses to sympathetic nerve stimulation, norepinephrine (Cay-16673), and vasopressin in pithed rats when administered at a dose of 150 nmol/kg.Formal Name: L-alanylglycyl-L-threonyl-L-alanyl-L-alpha-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (6->11)-disulfide, trifluoroacetate salt. Synonyms: U-II, Urotensin II (G. mirabilis). Molecular Formula: C62H84N14O17S2 . XCF3COOH. Formula Weight: 1361.5. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: [H]N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C1=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CNC4=C3C=CC=C4)=O)CC5=CC=CC=C5)=O)CSSC[C@H](N1)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC(O)=O)=O)C)=O)=O)=O)C.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C62H84N14O17S2.C2HF3O2/c1-31(2)50(62(92)93)76-60(90)47-30-95-94-29-46(73-58(88)45(26-49(80)81)69-53(83)33(4)67-61(91)51(34(5)77)75-48(79)28-66-52(82)32(3)64)59(89)71-42(23-35-13-7-6-8-14-35)55(85)72-44(25-37-27-65-40-16-10-9-15-39(37)40)57(87)68-41(17-11-12-22-63)54(84)70-43(56(86)74-47)24-36-18-20-38(78)21-19-36,3-2(4,5)1(6)7/h6-10,13-16,18-21,27,31-34,41-47,50-51,65,77-78H,11-12,17,22-26,28-30,63-64H2,1-5H3,(H,66,82)(H,67,91)(H,68,87)(H,69,83)(H,70,84)(H,71,89)(H,72,85)(H,73,88)(H,74,86)(H,75,79)(H,76,90)(H,80,81)(H,92,93),(H,6,7)/t32-,33-,34+,41-,42-,43-,44-,45-,46-,47-,50-,51-,/m0./s1. InChi Key: JPLUDFUGUYKDAT-OKRJWCIQSA-N.