Tertiapin LQ (trifluoroacetate salt)

Tertiapin LQ is a peptide derivative of the honeybee venom peptide tertiapin and an inhibitor of inwardly rectifying potassium (Kir) channels. It inhibits heteromultimeric potassium channels composed of G protein-activated inward rectifier potassium channel 1 (GIRK1) and GIRK4, also known as Kir3.1 and Kir3.4, respectively, as well as the inward-rectifier potassium channel 1 (Kir1.1). In vivo, tertiapin LQ suppresses the Purkinje cell pause response to a conditional stimulus in ferrets. Formal Name: 2,2'-((2S,5S,8R,11S,14S,17S,20R,25R,28S,31S,34S,37S,40S,42aS,49S,52R)-11-((1H-indol-3-yl)methyl)-20-((2-(((S)-6-amino-1-(((S)-1,6-diamino-1-oxohexan-2-yl)amino)-1-oxohexan-2-yl)amino)-2-oxoethyl)carbamoyl)-5-(3-amino-3-oxopropyl)-14,17-bis(4-aminobutyl)-52-((S)-2-((S)-2-aminopropanamido)-4-methylpentanamido)-34,37,40-tri((S)-sec-butyl)-31-(3-guanidinopropyl)-2-isobutyl-3,6,9,12,15,18,26,29,32,35,38,41,42,48,51-pentadecaoxodotetracontahydro-1H,24H-25,8-(epiminoethanoiminopropanodithiomethano)pyrrolo[1,2-x][1,2]dithia[5,8,11,14,17,20,23,24,29,32,35,38,41]tridecaazacyclotetratetracontine-28,49-diyl)diacetamide, trifluoroacetate salt. Synonyms: TPNLQ. Molecular Formula: C106H179N33O24S4 . XCF3COOH. Formula Weight: 2428.0. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: ALCNCNRIIIPLQCWKKCGKK-NH2. Solubility: Water: Soluble. SMILES: [H]N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(N1CCC[C@H]1C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C2=O)=O)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N3)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)CSSC[C@H](N2)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C3=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)=O)=O)C.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C106H179N33O24S4.C2HF3O2/c1-12-56(8)83-103(161)137-84(57(9)13-2)104(162)138-85(58(10)14-3)105(163)139-42-26-34-78(139)102(160)131-70(44-55(6)7)94(152)126-68(35-36-79(112)140)92(150)133-75-51-166-167-52-76(134-95(153)69(43-54(4)5)127-87(145)59(11)111)100(158)130-73(47-81(114)142)98(156)135-77(101(159)129-72(46-80(113)141)97(155)125-67(93(151)136-83)33-25-41-118-106(116)117)53-165-164-50-74(88(146)120-49-82(143)121-64(30-18-22-38-108)89(147)122-63(86(115)144)29-17-21-37-107)132-91(149)66(32-20-24-40-110)123-90(148)65(31-19-23-39-109)124-96(154)71(128-99(75)157)45-60-48-119-62-28-16-15-27-61(60)62,3-2(4,5)1(6)7/h15-16,27-28,48,54-59,63-78,83-85,119H,12-14,17-26,29-47,49-53,107-111H2,1-11H3,(H2,112,140)(H2,113,141)(H2,114,142)(H2,115,144)(H,120,146)(H,121,143)(H,122,147)(H,123,148)(H,124,154)(H,125,155)(H,126,152)(H,127,145)(H,128,157)(H,129,159)(H,130,158)(H,131,160)(H,132,149)(H,133,150)(H,134,153)(H,135,156)(H,136,151)(H,137,161)(H,138,162)(H4,116,117,118),(H,6,7)/t56-,57-,58-,59-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,83-,84-,85-,/m0./s1. InChi Key: ZPLMSISGLVMRNO-BOYOOOHJSA-N.