TCCR, aa44-59, Blockng Peptide (T Cell Cytokine Receptor, WSX-1), Purified

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-g and lymphotoxin-b that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned (1,2). It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1 (1,2). TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-g and Th1-dependent antibody IgG2a (1). TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes., , Synthetic peptide (GSAGPLQCYGVGPLGD) corresponding to amino acids 44 to 59 of human TCCR precursor (1).