Syntide-2

Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII, Km = 12 µM). Its sequence is derived from the phosphorylation site 2 on glycogen synthase, a target of CaMKII action. This peptide has been used as a probe to assay CaMKII activity, however, protein kinase C, CaMKV, Raf-1, and other kinases are also known to recognize syntide-2 as a substrate.Formal Name: L-prolyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-leucyl-L-seryl-L-valyl-L-alanylglycyl-L-leucyl-L-prolylglycyl-L-lysyl-L-lysine. CAS Number: 108334-68-5. Molecular Formula: C68H122N20O18. Formula Weight: 1507.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: Soluble. SMILES: O=C(N(CCC1)[C@@H]1C(NCC(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)[C@H](CC(C)C)NC(CNC([C@H](C)NC([C@H](C(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@]([C@H](O)C)([H])NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H]2CCCN2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O. InChi Code: InChI=1S/C68H122N20O18/c1-35(2)29-46(83-57(95)42-21-16-26-73-42)60(98)77-40(10)56(94)81-44(22-17-27-74-68(71)72)59(97)87-54(41(11)90)65(103)84-47(30-36(3)4)61(99)85-49(34-89)62(100)86-53(38(7)8)64(102)78-39(9)55(93)75-32-52(92)80-48(31-37(5)6)66(104)88-28-18-23-50(88)63(101)76-33-51(91)79-43(19-12-14-24-69)58(96)82-45(67(105)106)20-13-15-25-70/h35-50,53-54,73,89-90H,12-34,69-70H2,1-11H3,(H,75,93)(H,76,101)(H,77,98)(H,78,102)(H,79,91)(H,80,92)(H,81,94)(H,82,96)(H,83,95)(H,84,103)(H,85,99)(H,86,100)(H,87,97)(H,105,106)(H4,71,72,74)/t39-,40-,41+,42-,43-,44-,45-,46-,47-,48-,49-,50-,53-,54-/m0/s1. InChi Key: NKBRRWBNPNUBDD-TYKVATLISA-N.