Substance P (1-7) (trifluoroacetate salt)

Substance P (1-7) is a peptide fragment of the neuropeptide substance P (Cay-24035). It is produced by proteolytic cleavage of substance P by neprilysin. Substance P (1-7) (10 nM) induces internalization of the neurokinin-1 (NK1) receptor in isolated rat striatal slices. It inhibits substance P-induced contralateral rotation in rats and substance P-induced substantia nigra dopamine release in anesthetized rats. Administration of substance P (1-7) into the nucleus tractus solitarius decreases mean arterial pressure and heart rate in anesthetized rats. Substance P (1-7) (1 nmol/animal) reduces withdrawal jumping in morphine-dependent mice when administered intrathecally. It increases the latency to tail-flick in the tail-flick test in streptozotocin-induced diabetic mice, an effect that can be reversed by naloxone or (+)-pentazocine but not naltrindole (Cay-9000705), beta-funaltrexamine (Cay-39901), norbinaltorphimine, or BD 1047 (Cay-22928). Substance P (1-7) (35 pmol/animal) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic-like activity.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: Ethanol: Slightly soluble: 0.1-1 mg/ml, PBS (7.2 pH): Sparingly soluble: 1-10 mg/ml.