SPACE Peptide (trifluoroacetate salt)

SPACE peptide is a skin-penetrating and cell-entering (SPACE) peptide. It is internalized in keratinocytes, fibroblasts, human umbilical vein endothelial cells (HUVECs), and MDA-MB-231 breast cancer cells via macropinocytosis, a form of endocytosis. SPACE peptide-containing conjugates have been used to deliver proteins and siRNA in vitro and in vivo.. SMILES: O=C(N[C@H](C(N[C@@H](CSSC[C@@H](C(N[C@@](C(NCC(N[C@H](C(N[C@@](C(N[C@H](C(N1)=O)CCC(N)=O)=O)([H])[C@H](O)C)=O)CO)=O)=O)([H])[C@H](O)C)=O)NC([C@@H](N)C)=O)C(NCC(O)=O)=O)=O)CCC(N)=O)[C@@H]1CC2=CN=CN2.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C40H63N15O17S2.C2HF3O2/c1-16(41)32(64)52-25-14-74-73-13-24(33(65)46-11-29(62)63)53-35(67)20(4-6-26(42)59)49-36(68)22(8-19-9-44-15-47-19)51-34(66)21(5-7-27(43)60)50-40(72)31(18(3)58)55-37(69)23(12-56)48-28(61)10-45-39(71)30(17(2)57)54-38(25)70,3-2(4,5)1(6)7/h9,15-18,20-25,30-31,56-58H,4-8,10-14,41H2,1-3H3,(H2,42,59)(H2,43,60)(H,44,47)(H,45,71)(H,46,65)(H,48,61)(H,49,68)(H,50,72)(H,51,66)(H,52,64)(H,53,67)(H,54,70)(H,55,69)(H,62,63),(H,6,7)/t16-,17+,18+,20-,21-,22-,23-,24-,25-,30-,31-,/m0./s1. InChi Key: AXNCHTPJXDDRQS-ZRADMUGUSA-N