Saralasin (trifluoroacetate salt)

Saralasin is a peptide angiotensin II type 2 (AT2) receptor agonist. It binds to AT2 receptors (Ki = 0.38 nM) and induces neurite outgrowth in NG108-15 cells when used at a concentration at 100 nM, an effect that can be inhibited by the AT2 receptor antagonist PD 123310. Saralasin (5 µg/animal, i.c.v.) enhances acquisition of the conditioned avoidance response in rats.Formal Name: N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-alanine, trifluoroacetate salt. Synonyms: Aralasin, 1-Sar-8-Ala-Angiotensin II. Molecular Formula: C42H65N13O10 . XCF3COOH. Formula Weight: 912.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@@H](C)C(O)=O)=O)CCC3)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C42H65N13O10.C2HF3O2/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65,3-2(4,5)1(6)7/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47),(H,6,7)/t24-,28-,29-,30-,31-,33-,34-,/m0./s1. InChi Key: MSJJUBUOJZCFIK-LYHTUURTSA-N.