Rabies virus (Glycoprotein) Peptide Pool

Pool of 129 peptides derived from a peptide scan (15mers with 11 aa overlap) through Glycoprotein (Uni-Prot ID P19462) of Rabies virus (strain HEP-Flury). One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. [The UniProt Consortium]