QMT-CBT

Description: QMT-CBT is a near-infrared aggregation-induced emission compound. Upon activation of caspase1 (Cas1), QMT-CBT undergoes a CBT-Cys click reaction, forming a cyclic dimer known as QMT-Dimer (the first aggregate), which further assembles into nanoparticles (the second aggregate). This process turns on the AIE signal, enhancing imaging for Alzheimer's disease (AD). Smiles: CCN1C2=CC=CC=C2C(=C(C#N)C#N)C=C1/C=C/C3=CC=C(S3)C4=CC=C(C=C4)N(C5=CC=CC=C5)C6=CC=C(C=C6)C7=CC=C(C=C7)OCCN8C=C(N=N8)C[C@@H](C(=O)NC9=CC1=C(C=C9)N=C(S1)C#N)NC(=O)[C@H](CSSC(C)(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)C