PTP IA-2, human Peptide Pool

Pool of 242 peptides derived from a peptide scan (15mers with 11 aa overlap) through receptor-type tyrosine-protein phosphatase IA-2 (Uni-Prot ID Q16849) of Homo sapiens (Human). One unit allows the stimulation of 2,5 x 10^8 cells. Protein function: Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin- containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. [The UniProt Consortium]