Poneratoxin acetate

Description: Poneratoxin acetate is a neurotoxic peptide and modulator of NaV1.6/NaV1.7, lowering the activation threshold of voltage-gated sodium channels and causing pain. Target: Sodium Channel. Smiles: [H]N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N[C@]([H])(C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(N[C@]([H])(C(N3CCC[C@H]3C(N4CCC[C@H]4C(N[C@H](C(N[C@]([H])(C(N[C@H](C(N[C@@H](C)C(N[C@]([H])(C(N[C@@H](CC5=CN=CN5)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)=O)=O)=O)[C@@H](C)CC)=O)=O)CCC(N)=O)=O)[C@@H](C)CC)=O)C(C)C)=O)=O)=O)[C@H](O)C)=O)=O)CC(C)C)=O)CC(C)C)=O)CO)=O)=O)CC(C)C)=O)[C@@H](C)CC)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(C)C)=O.CC(O)=O. References: Robinson SD, et al., Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nat Commun. 2023 May 23,14(1):2977.