PLP (139-151) (trifluoroacetate salt)

PLP (139-151) is an encephalitogenic peptide fragment of myelin proteolipid protein (PLP). In vivo, PLP (139-151) (150 µg/animal) induces the formation of inflammatory foci, axonal injury, and demyelination in the spinal cord, as well as motor deficits in mice. It is commonly used to induce experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), in mice.Formal Name: L-histidyl-L-seryl-L-leucylglycyl-L-lysyl-L-tryptophyl-L-leucylglycyl-L-histidyl-L-prolyl-L-alpha-aspartyl-L-lysyl-L-phenylalanine, trifluoroacetate salt. Synonyms: linPLP, Proteolipid Peptide (139-151). Molecular Formula: C72H104N20O17 . XCF3COOH. Formula Weight: 1521.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Water: soluble. SMILES: N[C@@H](CC1=CN=CN1)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)CCC3)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C72H104N20O17.C2HF3O2/c1-40(2)25-51(63(99)80-36-60(95)84-55(30-45-34-77-39-82-45)71(107)92-24-14-21-58(92)70(106)89-54(31-61(96)97)68(104)85-50(20-11-13-23-74)66(102)90-56(72(108)109)27-42-15-6-5-7-16-42)86-67(103)53(28-43-32-78-48-18-9-8-17-46(43)48)88-65(101)49(19-10-12-22-73)83-59(94)35-79-64(100)52(26-41(3)4)87-69(105)57(37-93)91-62(98)47(75)29-44-33-76-38-81-44,3-2(4,5)1(6)7/h5-9,15-18,32-34,38-41,47,49-58,78,93H,10-14,19-31,35-37,73-75H2,1-4H3,(H,76,81)(H,77,82)(H,79,100)(H,80,99)(H,83,94)(H,84,95)(H,85,104)(H,86,103)(H,87,105)(H,88,101)(H,89,106)(H,90,102)(H,91,98)(H,96,97)(H,108,109),(H,6,7)/t47-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,/m0./s1. InChi Key: XUIHONJLEQCVEQ-OVFYYFFASA-N.